LEONI VALERIO
On appointement by email
Biography
Current position and title: associated professor of Clinical Biochemistry, School of Medicine, University of Milano-Bicocca with clinical activity as Director of the Laboratory of Clinical Pathology and Clinical Chemistry, Hospital of Desio, ASST-Biranza, Italy
Education and training
- Medical Degree (110/110 cum laude) at University of Insubria, September 1999;
- Specialization in Clinical Biochemistry, University of Insubria, November 2003;
- PhD in Clinical Chemistry, Karolinska Institutet, Stockholm, Sweden, March 2005.
- Scientific qualification as associated professor of Clinical Biochemistry (Abilitazione Scientifica Nazionale ANVUR, 05/E1: Biochimica e Biochimica Clinica), June 2014.
- Scientific qualification as full professor of Clinical Biochemistry (Abilitazione Scientifica Nazionale ANVUR, prima fascia, 05/E3: Biochimica Clinica), August 2018 – August 2026.
Professional experience and positions held
• November 1999 - November 2003: Laboratory of Clinical Chemistry, Hospital of Varese: specialisation in clinical biochemistry.
• November 2003 - June 2005: PhD student at Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska University Hospital in Huddinge, Stockholm, Sweden.
Research about oxysterols as biomarkers in neurodegenerative diseases. Active at the local laboratory of Clinical Chemistry.
• June 2005 – September 2014: MD, PhD at the Laboratory of Clinical Pathology and Medical Genetics, IRCCS Fondazione Istituto Neurologico Carlo Besta, Milano.
Responsible for the mass spectrometry laboratory of diagnostic metabolomics for the diagnosis of inherited metabolic diseases. By LC-MS/MS or GC-MS quantification of diagnostic biomarkers for the disorders of β-oxidation, organic acidurias, aminoacidic metabolism disorders, lysosomal storage disorders, mitochondrial diseases, peroxisomal diseases.
Research on the metabolic modifications in neurodegenerative diseases, degenerative diseases and aging.
• December 2010 - December 2014: Principal Investigator (PI) for "Study of cholesterol metabolism as a biomarker in Huntington disease: new insights in the pathogenesis of neurodegeneration”. Italian Ministry of Health, GR-2008-1145270. Project funded by Euro 485,500.
•Oct 2014 – Feb 2019: MD, PhD, resident Medical Doctor specialist in Clinical Biochemistry at the Laboratory of Clinical Chemistry, ASST-Settelaghi, Varese: Biochemistry, Clinical Chemistry, diagnostic haematology, thrombosis and haemostasis, protein biomarkers, Urinalysis, Analytical Chemistry, therapeutic drug monitoring. Research on metabolomics in degenerative diseases.
• March 2019 – nowadays: associate professor of Clinical Biochemistry and Clinic pathology, University of Milano Bicocca.
Director of the laboratory of Clinical Biochemistry, Hospital of Desio, ASST-Brianza. The laboratory perform 1.6 million analysis/year. Staff: 3 MD and 4 MS Biologist specialised in Clinical Biochemistry, 30 laboratory technicians, 10 nurses and 10 administrative employed. Activity: clinical chemistry, clinical biochemistry, protein biomarkers, CZE and immunofixation for monoclonal gammopathies, thrombosis and haemostasis, diagnostic haematology, urinalysis, toxicology, therapeutic drug monitoring, molecular biology, microbiology, transfusion medicine, counselling. The laboratory is equipped with 2 LC-MS/MS and 1 GC-MS used for toxicology diagnostic and metabolomics.
Research
Main filed of research is the application of mass spectrometry to diagnostic process in the laboratory of clinical biochemistry.
Research on metabolomics, lipidomics and metabolic biomarkers in aging, neurodegenerative and degenerative diseases.
Grants and awards
- 2010 PI of GR-2008-1145270 € 485500.
- 2013 PADDINGTON: biomarker discovery in HD. SienaBiotech, EuroHD € 44.000
- 2014 Biomarker Discovery and Testing of Cholesterol Pathway Intervention in HD, UniMi € 48.600
- 2019-ATE-0481 – Lipidomics in neurodegenerative diseases: 1.756,00 €
- 2020-ATE-0433, Metabolic responses to SARS-CoV-2 € 2.037
- 2021 Milano-Ricerche 2021-ECO-0115, SUSCETTIBILITA’ INDIVIDUALE AGLI EFFETTI DELLA TCDD SULLA QUALITA’ DEL LIQUIDO SEMINALE NELL’UOMO € 95.000
- 2021-ECO-0003, SOREMARTEC ITALIA Analisi di steroli e ossi(fito)steroli in prodotti finiti € 5.600
- 2018 National Academic Qualification Full Professor in Clinical Biochemistry (05/E3)
Author of 92 peer reviewed publications.
- Scopus Id: 36111393500
- ORCID ID: 0000-0002-8954-0366
- Scopus: 3155 citations, H-index 31;
- Scholar: 4274 citations, H-index 36.
Publications
Ksila, M., Ghzaiel, I., Sassi, K., Zarrouk, A., Leoni, V., Poli, G., et al. (2024). Therapeutic Applications of Oxysterols and Derivatives in Age-Related Diseases, Infectious and Inflammatory Diseases, and Cancers. In G. Lizard (a cura di), Implication of Oxysterols and Phytosterols in Aging and Human Diseases (pp. 379-400). Springer [10.1007/978-3-031-43883-7_19]. Detail
Lopergolo, D., Bianchi, S., Gallus, G., Locci, S., Pucci, B., Leoni, V., et al. (2023). Familial Alzheimer's disease associated with heterozygous NPC1 mutation. JOURNAL OF MEDICAL GENETICS [10.1136/jmg-2023-109219]. Detail
Raas, Q., Tawbeh, A., Tahri-Joutey, M., Gondcaille, C., Keime, C., Kaiser, R., et al. (2023). Peroxisomal defects in microglial cells induce a disease-associated microglial signature. FRONTIERS IN MOLECULAR NEUROSCIENCE, 16 [10.3389/fnmol.2023.1170313]. Detail
Birolini, G., Valenza, M., Ottonelli, I., Talpo, F., Minoli, L., Cappelleri, A., et al. (2023). Chronic cholesterol administration to the brain supports complete and long-lasting cognitive and motor amelioration in Huntington's disease. PHARMACOLOGICAL RESEARCH, 194(August 2023) [10.1016/j.phrs.2023.106823]. Detail
Tripodi, D., Vitarelli, F., Spiti, S., Leoni, V. (2023). The Diagnostic Use of the Plasma Quantification of 24S-Hydroxycholesterol and Other Oxysterols in Neurodegenerative Disease. In G. Lizard (a cura di), Implication of Oxysterols and Phytosterols in Aging and Human Diseases (pp. 337-351). Springer [10.1007/978-3-031-43883-7_17]. Detail
Awards
Awards
- RF-2021-12375279, Ministero della Salute, 2022
- Ricerca Finalizzata, Ministero della salute, 2008
- BLANCEFLOR-Boncompagni Ludovisi nee Bildt, BLANCEFLOR-Boncompagni Ludovisi, 2007
- assegno di ricerca, Stockholms-Odd Fellow-Logers Minnes-&Hillinings Fond, 2004
- BLANCEFLOR-Boncompagni Ludovisi nee Bildt, BLANCEFLOR-Boncompagni Ludovisi, 2003
Research and teaching assignments
- Ricercatore presso Ente di ricerca - Medical Doctor and Visiting Researcher - KAROLINSKA INSTITUTET, 2002 - 2003
- Ricercatore a t.d. presso Ente di ric. - Medico Specialista in Biochimica Clinica Ricercatore contrattista CoCoCo - FONDAZIONE IRCCS - ISTITUTO NEUROLOGICO CARLO BESTA, 2005 - 2014