FIANDRA LUISA

Luisa Fiandra is Researcher and Assistant Professor in Clinical Biochemistry at the Department of Biotechnology and Biosciences of University of Milano Bicocca, and she is also member of Centro 3R (Inter-University Center for the Promotion of the 3Rs Principles in Teaching & Research.

Up to 2017, LF coordinated pre-clinical studies mainly devoted to the use of nanotechnology for cancer therapy and diagnosis, and for biological barriers overcoming. These studies aimed to assess nanoparticles 1) interaction, internalization and trafficking in cells and animal tissues, 2) biological activity on target and non-target cells, 3) ability in crossing biological barriers (i.e., BBB) in vitro, and in vivo biodistribution, pharmacokinetic properties, therapeutic effect, and acute and sub-acute toxicity in murine models. From 2018, LF participate to EU projects aimed to determine the toxicity of different types of nanoproducts by in vitro assays and on alternative vertebrate models (Zebrafish), in line with the Safe-by-Design concept for the development of new nanoformulated nanotools. Currently, LF is devoted to the use of advanced cellular models for the validation of conventional or latest generation therapies directed towards tumor pathologies. The research activity is now mainly focused on the study of the tumor-associated immune system activation and ADCC, and on innovative strategies involving tumor microenvironment cells reprogrammed by genetic approaches to eradicate desmoplastic tumors.