CAZZANIGA GIOVANNI
Biography
EDUCATION
2021 - Associate Professor, Medical Genetics, School of Medicine and Surgery, Univ. Milan Bicocca.
2018 - Assistant Professor (Ricercatore a Tempo Determinato di tipo B, RTDB), Medical Genetics, School of Medicine and Surgery, Univ. Milan Bicocca.
2014 - Qualification (National Scientific Habilitation, ASN) for Associate Professorship to the following sections: 05/F1 Applied Biology BIO/13 and 06/A1 Medical Genetics MED/03, 06/A2 General and Clinical Pathology (deadline 07/01/2023).
2004 - Specialist in Medical Genetics. Faculty of Medicine, University of Milan, Italy. 70/70 cum laude.
1992 - Specialist in Pharmaceutical Research at the “M.Negri” Pharmacology Research Institute of Milan, Italy.
1990 - Biological Science degree at the University of Milan, Italy. 110/110 cum laude.
PROFESSIONAL POSITION
05/2023 - now: Acting Director (ff), Medical Genetics, Foundation IRCCS San Gerardo dei Tintori, Monza, Italy
03/2023 - now: Deputy Director, Ph.D. Program in Translational and Molecular Medicine (Dimet), University of Milan Bicocca.
12/2021 - now: Associate Professor, Medical Genetics, School of Medicine and Surgery, Univ. Milan Bicocca.
2006 - now: Head, “Molecular genetics of leukemia” Unit, Centro Tettamanti, Fondazione Tettamanti, Monza, Italy.
2018-2021: Assistant Professor (Ricercatore a Tempo Determinato di tipo B, RTDB), Medical Genetics, School of Medicine and Surgery, Univ. Milan Bicocca.
2009 - 04/2023: Director, Laboratory of Hemato-Oncology Diagnostics “M. Tettamanti”, Fondazione MBBM, Monza.
1995/1997: Research fellow at the “M.Tettamanti” Research Center, Pediatric Clinic, University of Milan-Bicocca, Ospedale San Gerardo, Monza, Italy.
1990/1994: Research fellow at the Laboratory of Enzymology - Molecular Biology Unit - "M.Negri" Pharmacology Research Institute, Milan, Italy.
Research
MAJOR RESEARCH INTERESTS
- Genetic predisposition to childhood acute lymphoblastic leukemia (ALL)
- Prenatal origin of ALL
- Molecular characterization of childhood ALL
- Functional analysis of genetic aberrations in leukemic patients (PAX5 lesions, Ph-like ALL, Down Syndrome ALL, MLL-rearrangements) and in vitro/in vivo drug targeting
- Minimal residual disease monitoring in childhood ALL, by analysis of T-cell Receptor and Immunoglobulin genes’ rearrangements.
Publications
Acunzo, D., Bertagna, M., Risca, G., Beneforti, L., Bresolin, S., Galimberti, S., et al. (2026). Targeting oncogene-induced senescence in ETV6::RUNX1 pre-leukemic cells. CELL DEATH DISCOVERY, 12(1) [10.1038/s41420-026-03001-5]. Detail
Cavar Pavic, J., Cullinan, N., Jongmans, M., Bourdeaut, F., Wadt, K., Lonigro, L., et al. (2026). Challenges in identifying paediatric cancer predisposition syndromes: international SCOPE survey and SIOPE expert consensus recommendations. EUROPEAN JOURNAL OF HUMAN GENETICS [10.1038/s41431-026-02040-x]. Detail
Peccatori, N., Curto, A., Silvestri, D., Rebellato, S., Antic, Z., Bhatia, S., et al. (2026). PEDIATRIC PAX5-REARRANGED ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) IS A HIGH-RISK MOLECULAR SUBGROUP OF B-ALL WITH A POOR MRD-DEPENDENT PROGNOSTIC PROFILE. HAEMATOLOGICA, 111(1), 1-1 [10.3324/haematol.2026.s1.54]. Detail
Franco, G., Bruno, L., Alviano, A., Vankann, L., Brümmendorf, T., Guerra, F., et al. (2026). Cytopenia, Hypocellular Bone Marrow, and Shortened Telomere Length Beyond Biallelic Telomere Biology Gene Mutations. PEDIATRIC BLOOD & CANCER, 73(4 (April 2026)) [10.1002/1545-5017.70150]. Detail
Rigotti, L., Rebellato, S., Lettieri, A., Castiglioni, S., Mariani, M., Totaro, S., et al. (2025). Cohesins: Crossroad Between Cornelia de Lange Spectrum and Cancer Predisposition. AMERICAN JOURNAL OF MEDICAL GENETICS. PART A, 197(8) [10.1002/ajmg.a.64076]. Detail
Research projects
Awards
Scientific fellowships
- Componente del Comitato Scientifico - Comitato REgionale per i Servizi di MEdicina di Laboratorio (CRESMEL) - Regione Lombardia, 2023
- Componente dell'Advisory Board - project “Responsible Initiative on Neonatal Genome Sequencing” (RINGS), 2022
- Componente del Comitato Scientifico - Comitato Tecnico Scientifico di Associazione Italiana per la Ricerca sul Cancro (AIRC), 2016
- Componente del Consiglio/Comitato Direttivo - Euroclonality-NGS (WG of ESHLO, an official Specialized Working Group of the European Hematology Association), 2015
- - European Group for Minimal Residual Disease (EuroMRD), 2001
Editorial boards
- Associate Editor di rivista o collana editoriale - FRONTIERS IN PEDIATRICS, 2022
Congresses/Conferences
- Program committee - ESLHO Symposium(Paesi Bassi), 2025
- Program committee - AIEOP...in Lab(Italia), 2025
- Program committee - AIEOP...in Lab(Italia), 2025
- Program committee - ESHLO Symposium(Portogallo), 2024
- Program committee - ESHLO Symposium(Spagna), 2023
- Program committee - AIEOP...in Lab(Italia), 2023
- Program committee - ESHLO Symposium(Polonia), 2022
- Program committee - ESHLO Symposium(Paesi Bassi), 2021
- Program committee - ESHLO Symposium, 2020
- Program committee - ESHLO Symposium(Belgio), 2019
- Program committee - ESHLO Symposium(Germania), 2018
- Program committee - AIEOP...in Lab(Italia), 2018
- Program committee - ESHLO Symposium(Paesi Bassi), 2017
- Program committee - ESHLO Symposium(Repubblica Ceca), 2016
- Program committee - ESHLO Symposium(Svizzera), 2015
- Program committee - AIEOP...in Lab(Italia), 2015
- Program committee - ESHLO Symposium(Spagna), 2014
- Program committee - ESHLO Symposium(Paesi Bassi), 2013
- Program committee - AIEOP...in Lab(Italia), 2009