CHIARADONNA FERDINANDO
- U04, Floor: 5, Room: 5020
By appointment
Biography
Academic and organizational activities
- 2023: Board member as Commissioner for an assistant professor position at the University of Piemonte Orientale, Novara, Italy
- 2022: Board member as President for an assistant professor position at the University of Milano Bicocca, Milano, Italy
- 2022: Board member as Commissioner for an assistant professor position at the University of Firenze, Firenze, Italy
- 2020 to date: member of the Scientific - Didactic Council of the Interuniversity Center for the promotion of the principles of 3R in teaching and research
- 2020 to date: member of the Teaching Quality Assurance for the Bachelor degree in Biotechnology and for the Master degree in Industrial Biotechnology
- 2020-2021: External supervisor for final thesis assessment of the PhD programs in University of Catanzaro and Roma Tre
- 2018-2021: Member of the Department Board (second term) at the Department of Biotechnology and Biosciences of the University of Milan Bicocca, Milan, Italy
- 2018: External supervisor for final thesis assessment of the PhD program in Biomedical and Neuromotor Sciences of the University of Bologna, Bologna, Italy
- 2018: External supervisor for final thesis assessment of the PhD program in Clinical and Experimental Oncology and Immunology of the University of Padua, Padua, Italy
- 2018: Board member for the final examination of the European School of Molecular Medicine (SEMM) PhD program, University of Milan, Milan, Italy
- 2018 to date: member of the national register of expert peer reviewers for Italian scientific evaluation (Italian Government)
- 2017 to date: Board Member of the PhD program in Converging Technologies for Biomolecular Systems (TECSBI) at the University of Milan Bicocca, Milan, Italy
- 2015-2018: Member of the Department Board at the Department of Biotechnology and Biosciences of the University of Milan Bicocca, Milan, Italy
- 2014-2016: Board Member of the PhD program in Biology and Biotechnology at the University of Milan Bicocca, Milan, Italy
- 2013: Board Member of the PhD program in Life Sciences at the University of Milan Bicocca, Milan, Italy
- 2012: Board member for the final examination of the PhD in Oncology, University of Perugia, Perugia, Italy
- 2006-2012: Board Member of the PhD program in Industrial Biotechnology at the University of Milan Bicocca, Milan, Italy
- 2011: Board Member for the final examination of the European School of Molecular Medicine (SEMM) PhD program, University of Milan, Milan, Italy
- 2007: Board member as Commissioner for an assistant professor position at the Faculty of Medicine and Surgery, disciplinary sector Biochemistry, University of Florence, Florence, Italy
- 11/2006-12/2007: Scientific tutor for Ingenio fellows (as expert in the technical feasibility of the research project), for a total of 352 hours, at the University of Milan-Bicocca, on behalf of the Lombardy Region as part of the INGENIO Project, "Development and consolidation of entrepreneurship with priority to new areas of employment" and "Improvement of human resources in the research and technological development sector"
- 2004-2009: Educational manager of the Professionalising Laboratory of Cellular Biochemistry Technologies, Bachelor in Biotechnology, University of Milano Bicocca, as part of the FSE-LIKE Project (European Social Fund)
- 2002 to date: Scientific supervisor for Bachelor, Master and PhD students - Biotechnology and Biosciences Dept, University of Milano-Bicocca, Milan, Italy
- 2002 to date: Scientific supervisor for Master thesis of the Erasmus Program
University Teaching
- 2002-2010: Cellular Biochemistry, Bachelor in Biotechnology
- 2010-2012: Biochemistry II, Bachelor in Biotechnology
- 2002-2016: Cellular Biochemistry Laboratories, Bachelor in Biotechnology
- 2019 to date: Cellular Biochemistry Laboratories, Bachelor in Biotechnology (last academic year by online teaching and creating e-learning resources). Student satisfaction for this course is around 2.6 on 3
- 2012 to date: Tumor Biochemistry, Master in Industrial Biotechnology (last academic year by online teaching and creating e-learning resources). Student satisfaction for this course is around 2.7 on 3. 2019/2020 new type of analysis: Organizational aspects 8.12 on 10; Didactic effectiveness 9,24 on 10; Student satisfaction 8,87 on 10.
NON-ACADEMIC SCIENTIFIC ACTIVITIES
1. Grant Reviewer
- 2010: AICR (Association for International Cancer Research)
- 2011: Dutch Childhood Oncology Group - DCOG (Stinchting Kinderoncologie Nederland - SKION)
- 2018: National Science Centre (Narodowe Centrum Nauki, Poland)
- 2019: Joint Project University of Verona
- 2020: Junior Individual fellowship, University of Varese Insubria
- 2020-2022: Invited by the European Community for the evaluation of proposal Individual Fellowships, Marie Skłodowska-Curie Actions
- 2020-2023: Invited as scientific expert by MIUR (REPRISE)
- 2023: Invited as expert by the European Commission for the evaluation of proposals submitted to the Horizon Europe Mission Cancer topic: HORIZON-MISS-2023-CANCER-01-01 (Bruxelles, Belgium)
2. Journal Reviewer for the following scientific journals: Oncogene, Cell Death and Disease, iScience, Molecular Cancer Therapeutics, BBA -Molecular Cell Research, BBA -Molecular Basis of Disease, Expert Opinion on Therapeutic Targets, ISRN Cell Biology, Biotechnology Advances, Journal of Cellular Physiology, Journal of Cellular Biochemistry, Bioinformatics, Anti-Cancer Agents in Medicinal Chemistry, BioMed Research International, Current Metabolomics, Bioscience Reports, Molecular Cancer Research, Metabolites, Cancer Letters, Molecules, Cell Biology International, Journal of Cancer and Tumor International, Antioxidants and Redox Signaling, Hepatology, BMC Cancer, PLOS One, Frontiers in Oncology, Cancer Chemotherapy and Pharmacology, BBA -General Subjects-, BMC Biology, Seminars in Cell and Developmental Biology, International Journal of Molecular Sciences, Open Life Sciences, Cells, Cancers, Antioxidant, Biomolecules
3. Editorial Board Member
- 2022 to date: Review Editor for Frontiers in Oncology, section Cancer Metabolism
- 2021 to date: Guest editor for the Topical collection “Pathometabolism: Understanding Disease through Metabolism”, Cells
- 2020 to date: Section Board member for Cells
- 2020-2021: Guest editor for the special issue: “Metabolic Rewiring in Cancer Cells: From Tumor Onset to Novel Therapies”, Cells (29 articles)
- 2011-2017: Board member for ISRN Cell Biology
- 2017 to date: Editor Board member for Oxidative Medicine and Cellular Longevity
- 2013 to date: Editor Board member for BioMed Research International
- 2014-2018: Board member for Journal of Cells
4. Project and Society member
- Member of the international Team “Deregulated metabolism'' part of the Halifax Project in Carcinogenesis
- Member of the international Team “SysRev SOP: Hallmark and key characteristics mapping”
- Member of Italian Society of Biochemistry
- Member of Italian Association of Cell Culture
- Member of Italian Group of Bioenergetics and Biomembranes
- Member of International Society of Cancer Metabolism
- Member of European Association for Cancer Research
AWARDED FELLOWSHIPS
- 1994-1996: Three-year fellowship from the Italian Cancer Research Association (International Institute of Genetics and Biophysics, Naples, Italy)
- 2000-2002: Annual fellowship of the Italian Foundation for Cancer Research "Detection of cancer gene mutation and expression profiling by nanotechnology" (European Institute of Oncology, Milan, Italy)
- 2002-2003: Annual fellowship from the European Institute of Oncology Foundation and the Italian Foundation for Cancer Research (Milan, Italy)
AWARDED GRANTS
- 2007: Progetti di Rilevante Interesse Nazionale (PRIN-Italian Government) (Principal Investigator) “Identification of the role of Sestrin 2 in tumorigenesis by a mouse KO approach” (positive result, not funded for lack of resources), (Principal Investigator)
- 2008-2012: Progetti di Rilevante Interesse Nazionale (PRIN-Italian Government) “Transcriptional, Proliferative and Metabolic analyses of 3AB-OS Cancer Stem Cells Compared to MG-63 osteosarcom Cells”, (Unit Principal Investigator)
- 2009-2022: Fondi Agevolazione Ricerca (FAR-Italian Government) (Principal Investigator)
- 2010-2015: MIUR SysBioNet, Italian Roadmap for European Strategy Forum on Research Infrastructures (ESFRI), (Cancer cell Unit Principal Investigator)
- 2015-2017: Italian Association for Cancer Research (AIRC), “Molecular targeting of the hexosamine biosynthetic pathway in pancreatic cancer as a novel therapeutic strategy” (Principal Investigator)
- 2017: Fondo per il finanziamento delle attività base di ricerca. Bando: FFABR 2017 (Italian Government) (Principal Investigator)
- 2019-2022 Executive Programme of Scientific Collaboration between Italy and China, Innovative Biomedical Devices (BIOMED), (Ministry for Foreign Affairs and International Cooperation), “Preclinical evaluation of a novel PGM3 inhibitor in pancreatic ductal adenocarcinoma” (Principal Investigator)
- 2020-2021 COVID-19 project from Regione Lombardia, “COVitaminD Trial: Prevention of COVID19 Complications in Cancer Patients”, (Unit Principal Investigator)
- 2021-2023 Competitive Project of University of Milano Bicocca (Principal Investigator)
SCIENTIFIC ACHIEVEMENTS
- VQR 2011-2014: National evaluation of the personal research quality by Italian Government: Excellent (2) (maximum)
- VQR 2015-2019: National evaluation of the personal research quality by Italian Government: Excellent (3) (maximum)
- 2015: Journal Cover for the article: Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer. Chiaradonna et al., Antioxidants & Redox Signaling. Volume 23, Issue 1/July 1, 2015
- 2020: Award for the best Publication in the Journal “Cells”
Publications
De, V., Battaglia, A., Pallocca, M., Santamaria, G., Mimmi, M., Sacco, A., et al. (In corso di stampa). ALDOC- and ENO2- driven glucose metabolism sustains 3D tumor spheroids growth regardless of nutrient environmental conditions: a multi-omics analysis. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH [10.21203/rs.3.rs-2128950/v1]. Detail
Zerbato, B., Brancato, V., Gobbi, M., Pessina, A., Brambilla, L., Wegner, A., et al. (2024). Targeting the Unfolded Protein Response for Breast and Pancreatic Cancer Therapy. Intervento presentato a: FEBS 2024, Milan, Italy. Detail
Zerbato, B., Brancato, V., Gobbi, M., Pessina, A., Brambilla, L., Wegner, A., et al. (2024). Targeting the Unfolded Protein Response for Breast and Pancreatic Cancer Therapy. Intervento presentato a: FEBS YSF 2024, Pavia, Italy. Detail
Yang, L., Zerbato, B., Pessina, A., Brambilla, L., Andreani, V., Frey-Jakobs, S., et al. (2024). PGM3 insufficiency: a glycosylation disorder causing a notable T cell defect. FRONTIERS IN IMMUNOLOGY, 15 [10.3389/fimmu.2024.1500381]. Detail
Venturi, S., Chiaradonna, F., Gatti, F., La Ferla, B., Parolini, R., Zerbato, B. (2024). Chiral trimethyl lock based on vicinal disubstituent effect: prolonged release of Camptothecin into cancer cells. CHEMICAL COMMUNICATIONS, 60(51), 6524-6527 [10.1039/d4cc01220h]. Detail
Research projects
Awards
Awards
- "Short Term Fellowship" from the Italian Fundation for Research on Cancer (FIRC), 2002
- "Short Term Fellowship" from the Italian Fundation for Research on Cancer (FIRC), 2001
- "Short Term Fellowship" from the Italian Fundation for Research on Cancer (FIRC), 2000
- AIRC Triennial Fellowship, AIRC, 1994
Scientific fellowships
- Fellow - European Molecular Biology Organization, 1996
Editorial boards
- Membro del Comitato Editoriale - FRONTIERS IN ONCOLOGY, 2022
- Guest Editor di rivista o collana editoriale - CELLS, 2021
- Membro del Comitato Editoriale - CELLS, 2021
- Guest Editor di rivista o collana editoriale - CELLS, 2020
- Membro del Comitato Editoriale - OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2017
- Membro del Comitato Editoriale - JOURNAL OF CELLS, 2015
- Membro del Comitato Editoriale - BIOMED RESEARCH INTERNATIONAL, 2012
Congresses/Conferences
- Partecipazione al comitato organizzativo - The role of 3Rs in the age of one health: where we are and where we’re going(Italia), 2023
- Program committee - 62nd SIB National Congress(Italia), 2023
- Program chair - Understanding cancer metabolism: exploring tumor heterogeneity to advance cancer therapy(Italia), 2023
- Partecipazione al comitato organizzativo - Adaptive mechanisms in cancer drug resistance(Italia), 2022
- Program chair - From genes to metabolites through proteins: dealing with human health and disease(Italia), 2022
- Program committee - 61° Italian Society of Biochemistry and Molecular Biology, 2021
- Altro ruolo - 60th Congress of the Italian Biochemistry and Molecular Biology Society Cancer and metabolism: chicken or egg?(Italia), 2019
- Program committee - Molecular, cellular and translational approaches to differentiation and neoplastic transformation(Italia), 2019