BECCHETTI ANDREA
- U03, Floor: 3, Room: 3041
- U03, Floor: 3, Room: 3010
Appointment by E-mail.
Biography
Andrea Becchetti received his academic degrees at the University of Milan. Subsequently, he spent prolonged research sojourns at the University of Florence (Department of General Pathology; 1990-1992), the Emory University School of Medicine of Atlanta (Department of Physiology; 1993-1994); the University of Newcastle-upon-Tyne (Department of Physiological Sciences; 1995-1996), and the Biophysics Sector of the International School for Advanced Studies (ISAS-SISSA) of Trieste (1997-1999).
In 2000, he was appointed Assistant Professor (Associate Professor since 2005) at the University of Milano-Bicocca (Department of Biotechnology and Biosciences), where he presently teaches General Physiology and Neuroscience.
Research
- Regulation of local neuronal circuits in the mammalian prefrontal cortex, by acetylcholine and hypocretin (orexin). The ascending regulatory systems modulate vigilance, cognition and the sleep-waking cycle, with pathological implications in sleep-related epilepsy, narcolepsy, and epilepsy in general.
- Regulation of synaptogenesis by the cholinergic system.
- Functional study of mutant nicotinic receptor subunits linked to genetic epilepsies.
- Signaling interplay between voltage-gated potassium channels and integrin receptors, which regulates cell adhesion to the extracellular matrix, cell migration, neurite extension, and is implicated in tumor growth and invasiveness.
Publications
-
AMADEO, A., COATTI, A., Aracri, P., Ascagni, M., Iannantuoni, D., Modena, D., et al. (2018). Postnatal Changes in K+/Cl- Cotransporter-2 Expression in the Forebrain of Mice Bearing a Mutant Nicotinic Subunit Linked to Sleep-Related Epilepsy. NEUROSCIENCE, 386, 91-107 [10.1016/j.neuroscience.2018.06.030]. Detail
-
BECCHETTI, A., Crescioli, S., Zanieri, F., Petroni, G., Mercatelli, R., Coppola, S., et al. (2017). The conformational state of hERG1 channels determines integrin association, downstream signaling, and cancer progression. SCIENCE SIGNALING, 10(473), 1-13 [10.1126/scisignal.aaf3236]. Detail
-
Conti, V., ARACRI, P., Chiti, L., BRUSCO, S., Mari, F., Marini, C., et al. (2015). Nocturnal frontal lobe epilepsy with paroxysmal arousals due to CHRNA2 loss of function. NEUROLOGY, 84(15), 1520-1528 [10.1212/WNL.0000000000001471]. Detail
-
Aracri, P., Banfi, D., Pasini, M., Amadeo, A., & Becchetti, A. (2015). Hypocretin (orexin) regulates glutamate input to fast-spiking interneurons in layer V of the Fr2 region of the murine prefrontal cortex. CEREBRAL CORTEX, 25(5), 1330-1347 [10.1093/cercor/bht326]. Detail
-
Aracri, A., Consonni, S., Morini, R., Perrella, M., Rodighiero, S., Amadeo, A., et al. (2010). Tonic modulation of GABA release by nicotinic acetylcholine receptors in layer V of the murine prefrontal cortex. CEREBRAL CORTEX, 20(7), 1539-1555 [10.1093/cercor/bhp214]. Detail
Research projects
Awards
Awards
- Highly Cited Paper (Thomson Reuters), Thomson Reuters, 2015
- AIRC Triennial Fellowship, AIRC, 1990
Scientific fellowships
- Socio effettivo o corrispondente - American Physiological Society, 2016
- Socio effettivo o corrispondente - Society for Neuroscience, 2004
- Socio effettivo o corrispondente - Society of General Physiologists, 2000
- Socio effettivo o corrispondente - Società Italiana di Fisiologia, 2000
Editorial boards
- Membro del Comitato Editoriale - PEERJ, 2014 - 2020
- Guest Editor di rivista o collana editoriale - FRONTIERS IN PHYSIOLOGY, 2012
- Direttore di rivista, collana editoriale, enciclopedia - , 2012 - 2014
Management or corporate responsibility
- Direttore del Telethon Research Service: Functional Test of Ion Channels - FONDAZIONE TELETHON, 2004 - 2005
Research and teaching assignments
- Ricercatore all estero - Attività di ricerca al Department of Physiological Sciences - Newcastle University, 1995 - 1997
- Ricercatore all estero - Attività di ricerca nel Department of Physiology. - Emory University, 1992 - 1994